No disrespect ot the work, but I'm always a bit worried about a thing that starts with "we're swapping out the Python interpreter for a compiler". For example, this doesn't include generator support, which is a big part of my Python usage.
"Just" having the CPython bridge is so tempting, because your python code will work (modulo C extensions), plus we get all the performance work too. I believe you tried this, of course.
For VOC, is there a guide to calling Java code from Python code? I see you have Toga, but being able to write my own abstractions without much work would be neat.