It might not be ready for prime-time in some very critical systems (like a web browser for example) but it's honestly probably good enough for this, especially in combination with process jailing as you suggest. I might consider trying to patch Cells up to use PyPy's sandbox instead of the non-solution currently implemented (I cried (okay, groaned) when I heard about it-- yeagh), when I have time, and if nobody else does it first. I'm a bit worried anything I write now would get lost or broken in the incoming tide of patches/changes anyway.
The main problems with using PyPy's sandboxing is probably with communication to/out of the sandbox, which is apparently problematic. I also anticipate some complaints about relying on PyPy in the first place, which is rather abnormal compared to using CPython-- using and relying on PyPy-specific features is pretty much unheard of.