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ooooh totally was. He was deeply affected by Hume's attack on causation, so tried to come up with a coherent response. Ended up positing a whole bunch of wacky and (I think) true things about our embedded cognition, so I think it's probably fair to say that Critique of Pure Reason is the result of his beef with Hume.

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In the CPR, Kant proposes a synthesis of both rationalism and empiricism: although some knowledge comes from sensory experience, there are some things that we just know -- e.g., pure mathematics. So I'd say it's the result of his beef with everyone!

Doesn't this all go back to Plato, where Plato thought knowledge depended on the forms, because the flux of particulars cannot provide knowledge?

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