Reduced spatial awareness on the bad side (duh), so you'll be slightly more likely to stumble a bit or bump into something and seem clumsy
Certain sports are much harder and you pretty much couldn't compete in them - almost any sport involving a ball. However this leaves lots of sports and I was fairly successful in grappling sports afterwards
Low level fear - I don't have a spare and being actually blind is obviously orders of magnitude more impact on your life.