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Sure, my thought process is as follows:

Hindering the development is the increased caused of licensing from a monopoly instead of a duopoly where they would need to compete. Higher cost of development hinders the use, as we are talking about a tool, wherein its usefulness is linked to its use.

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Have you considered that the licenses made need not be broad, and that university licenses include milestone requirements to maintain the license?

I have not put significant thought into if making patents more specific would help the current situation. It could help or it could make relatively trivial derivative works a larger problem. That is actually some of what this article is about, wherein one group describes a tool in one system and another group describes it in a separate, more lucrative system. I'll leave the argument of if translating expression from prokaryotes to eukaryotes is trivial, but I am convinced the translation was significantly easier than the discovery and description of the system in the first place.

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