You can out-smartass them by replying "Actually, it is".
An anecdote is a single data point. It's usually dismissed for all sorts of reasons, many of them valid.
BUT: contrary to popular opinion, they can be interesting, or even significant, depending on your priors, the payoffs of different outcomes etc. It's become fashionable to repeat the lazy phrase above, similar to "correlation does not prove causation", or "a survey with n=<any number> is completely worthless".
Example: "I've never seen this tree before. I wonder if those fruits are edible" / "It's just an anecdote, but my father ate one of those, started throwing up 30min later, and died the same day".