And if you think users couldn't handle using one of those, there's nothing stopping someone from making an e.g. "Privoxy configurator + blocklist updater" browser extension that just serves as a client GUI to your ad-stripping proxy's control channel. (Or giving the daemon a system-tray icon that launches an Electron GUI or something.)
The development of ad-blockers outside of the browser kind of stalled ~5 years ago, but only because everyone has been pretty satisfied with the browser extension solution to the problem. Take it away, and other solutions will just come back into play, with all the modern lessons learned from building the browser-extensions brought in.