While they're punching a hole in the air, yes. Takeoff & landing in most modern commercial aircraft have some auto-throttle/auto-braking assistance, but those are still generally flown by hand on every flight. Note that the cargo airlines this article addresses are primarily working with a much older fleet of airplanes that the major passenger airlines got rid of, so their tech generally lags behind what you see on the flight deck of your travel flights.

No one has yet implemented a real point-to-point autopilot, and there are none in the pipeline for certification. It's possible there are engineers working on them, especially at Boeing/Airbus, but given airframe lifetimes at the major commercial carriers pilots are here for at least another 20 years with them, and probably 30-40 years at cargo carriers.

They still have to be alert and ready to take over during the flight.