The only thing I have noticed is that it seems not work well for females (my wife is annoyed about that).
Also strangely my blood sugar has been above normal lately which is strange because I don't eat a carb heavy diet and I have never had blood sugar problems. Last time it was checked it was ~105 mg/dl or so (and I was fasted of course).
I have had some theories about this but curious if anyone else seen this.