"An A380-F would be too fat to fly at a profit: The plane would hit the maximum payload (a constraint of weight) before its maximum cubic space (a constraint of volume). Its design can’t support the maximum payload required to generate a profit.
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The A380-F would be able to carry 60% more volume than the 747, but only 28% more weight. It wouldn’t be fully loaded at typical levels of air cargo density, or at least nothing close to what can be supported by the thrust capacity of the 747."
https://www.flexport.com/blog/airbus-a380-no-cargo-equivalen...
Remember that planes are already double decker (triple for A380). They look like this: https://qph.ec.quoracdn.net/main-qimg-4c732e2865f73d86b72c5a...
The bottom deck has fuel tanks, passenger bags, and space for cargo. The A380 (passenger version) is problematic for cargo because there are two passenger decks which means up to twice the lower deck taken up with baggage leaving less for the cargo.