Must say it was weird to stumble on this news here on HN first instead of on the KSP forum (where admitedly it was posted first); guess it's been a busy morning and I just missed it.
If I were to make a big change, it would be to add a stand-alone server. Not necessarily multi-player, but just something I can leave running and attach to. I have an itch for real-time missions (days and weeks long), plus I'd like to run multiple scenarios at once.
I guess what I'm saying is I hope Take-Two doesn't lose the _spirit_ of the game. It has let us ground-bound wanna-be rocket scientists the opportunity to play.
A stand-alone server would also be great for those of us that run the game with a different integrator (such as Principia for n-body physics). I too like real-time missions, at least short duration ones, and recently flew Vostok 1 in near real time (though less successfully).