I can't do it in two sentences, but this is approximately the version I teach to first-year non-CS undergrads:
A problem is called "NP" if I can give you a solution to it and you can easily verify that the solution is correct. For example, "find 3 different odd numbers that together add up to ten" (here's a possible solution: 3, 5, 7). What's awesome about this is that there are a lot of problems of that form where we don't know whether or not it's possible to find a solution to the problems before dying of old age -- or before the sun runs out of fuel, even though you could check the answer in a few minutes using pencil and paper. Nobody has ever figured out how to solve them fast, but it's a huge open question of whether they can be solved fast. The P = NP question is whether there exists a fast solution to any problem that you can verify easily if I give you a solution.
And it's not just of theoretical interest: some those problems underlie everything from cryptography (communicating and storing information securely using encryption) to things like optimizing airline routes or the way UPS chooses where to route packages. Amazingly, there's a set of problems that if you find way to solve any one of them fast, you can solve all problems in NP fast. Which means the NSA and everyone else will try to kidnap you to find out the secret. Fortunately, most people who study it don't think that there's a solution. But it's one of the most famous and important problems in computing, and nobody -- of some of the smartest people in the field -- has ever managed to prove it either way.
(Truth in advertising: We actually use subset sum as the example, and walk through it a little, but that's because we're trying to teach it in more detail than just telling the story. And have also taught a handwavy version of asymptotic analysis. If you want to show someone how hard it gets quickly, subset sum is a nice way to do it. The "talking" example above is, of course, an instance of subset sum, but it doesn't explain the general form of the problem.)