I always wondered why rooms tend to be rectangular pretty much all over the world. Googling for that suggests that it's a price thing, but I'm not convinced, since expensive homes still seem to prefer rectangular rooms.
Even contemporary buildings, with extremely weird and non-uniform facades, still tend to be grid-based on the inside.
I would be really interested if this preference study was also done in the real world, not just in VR.
Another related universal thing, why do we sleep with the head towards the wall (as opposed to the center of the room). Googling suggests a deep security measure, since the wall prevents attacks from behind you, which are the hardest to defend against.
Feng-shui deals with these kind of issues, if you move beyond the superstitious layer (have a turtle for money, ...)
By reading feng-shui books I learned to get a bit more intune with my inner feelings (the chi/qi), so now, if I sit in a room with no apparent exit, or with a cluttered path to the exit, I can pin point the insecurity feelings emanating from my subconscious.