If this is about Amazon thinking they can turn things around for Whole Foods, then it will certainly mean drastic changes to price, selection, and employee structure.
If this is about Amazon using a brick-and-mortar chain as a tool to help Amazon's own ventures (e.g. grocery delivery, local storage for same-day deliveries, product return and support locations, etc), then it will certainly mean drastic changes what a Whole Foods store even is.
Either way, I can't imagine a course in which Whole Foods as we know it isn't basically over. Which doesn't necessarily bother me (I migrated to Trader Joe's and similar competitors long ago), but does seem like a big deal in the grand scheme of things. The grocery industry was heading in a Walmart-ish direction... and Whole Foods was almost single-handedly responsible for bringing a counterculture into the mainstream, and forcing all the other chains to reverse course and up their game.