You can layer on certain guided thoughts (like mantras and chants), but meditative practice is more powerful the simpler it is. You must strip away as much as possible -- to just sit and bring the body, breath, and mind into sync using breath focus and an aware non-judgmental mind. There are many books written on the subject; I can personally recommend Mindfulness in Plain English (free version at http://www.urbandharma.org/udharma4/mpe.html).
Meditation of this form is key to transforming your entire life. It is the gateway or pathway you can use to find and accept your true self and see yourself and your life for what it is. It is how you truly see that you cannot escape the present moment and that you have the full ability to choose how you relate to it. Sogyal Rinpoche says it better than I: http://www.youtube.com/watch?v=0tIBYxed16s.