When growth numbers are consistently not hit. Always push for transparency at a smaller company - if there isn't one already, attempt to implement an all-hands meeting at least bi-weekly that reviews goals for the quarter / year and the company's progress. If direction is constantly changing at a 1 or 2 month cadence, it's likely that there may be a shakeup coming sooner rather than later.
It's wise to have a bit of cynicism when discussing company goals, progress, outcomes - things may not always be as bright as they seem. It's a good exercise to take these numbers and reduce them by a certain percentage, and see if those numbers are still good for company growth & stability.