Signal, Join.me, FaceTime, et cetera. I no longer accept invitations to communicate via Skype.
Signal actually looks great, but their Mac/PC client has been in beta since 2015 and isn't linked from the homepage -- I had to dig it up on their blog. Also, video chat has been in beta since March 2017. It's not clear if their beta non-phone client supports the beta video chat. Still, I'm digging their encryption.
I don't mean to shit over your suggestions, I really am looking for something better. But so far, nothing seems like a clear winner.
Video chat actually came out of beta in March [0]. The beta was released in February.