In high school we were creating a vacuum in a bell jar to do the 'drop a feather and drop a weight' experiment and my physics teacher asked it. "So if we didn't have our apparatus in there, and we sucked it dry, what would be in there?"
It makes a great interview question because it helps identify people who have a hard time holding an unknown concept in their head and working with it.
I asked that of one of the folks I interviewed for Google when I was there and we spiraled off into a discussion of branes and multi-dimensional manifolds and quantum wave equations[1].
[1] Fun interview and they got the job :-)