This is one of the first things you'll notice being in business for yourself. It's hard to arrange time off. One of the benefits of working for a company is that there's a team in place to make sure the train stays on the rails while you're gone.
You also don't get sick days.
The others who were waiting on my emails got a very sincere apology and explanation, and we were all good.
This goes to show that you only think you have to be there all the time.
That's one of the hardest parts of running your own business IMO. I had to have an op, recommended recuperation was 2weeks of bed rest, I was back working the next day; yes there were deleterious effects on my health.
Also, the flexible schedule allows for mini vacations whenever you need it, which helps a lot. It's great to be able to blow off work whenever an opportunity to do something great comes up, as long as you're disciplined about getting things done other times.
I take my computer with me everywhere I go, even on vacation. I've had conference calls in the morning and hit Disney World in the afternoon. Usually my customers don't even realize I'm out and about.
So while you could say that your not really on vacation just remote, you could look at it the other way and realize you could spend a month in Florida on vacation and still make a few bucks in the process. I've been on vacations that have paid for themselves simply by putting a little work in for half a day here and there.
It feels a lot more like vacation than work.
My experience is that you just have to force yourself to stop working. It's terribly easy to let your business tak over your life. Me, I just force myself to forget about everything but the bat-phone on Sundays.