or express disbelief that we didn't anticipate <fairly obvious outcome> as an unexpected side effect of immune system tailoring.
<fairly obvious outcome> is likely to be "large increase in incididence of autoimmune disorders"
<fairly obvious outcome> is likely to be "large increase in incididence of autoimmune disorders"
Right now immune ablation is pretty rough chemotherapy, but has nonetheless been shown to put multiple sclerosis and type 1 diabetes into remission. There are new approaches to targeted cell killing under development now (such as Oisin Biotechnologies' system) that should be much better, with minimal side-effects. Couple that with a cell therapy to accelerate replacement of immune cells and it looks pretty promising.