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If you're going to make a SPA, why the heck wouldn't you use one of the frameworks that has tons of tutorials, walkthroughs, supporting libraries, and a zillion asked and answered questions on SO? In other words why not use one of the top 5 frameworks of the current time? It seems efficient to do so to me.

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It's expedient for many reasons to use a major framework, but it doesn't mean there are no drawbacks.

There are learning curves, inner platform effect (have to do the framework way of doing things), major breaking changes and outdated information, opinionated authors you may not agree with, huge dependencies for users to download, performance bottlenecks and gotchas arising from not using the framework properly or even the framework itself is slow. These things are basically guaranteed.

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