Source? Or did you forget?
At its worse, you start to talk about a topic, branch into a subtopic, and are unable to find your way back. You find yourself asking people "what was I talking about?" all of the time, imagine doing this in the middle of a presentation or while talking to a client.
Relevant Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931635/
Or do you mean while NOT impaired, as a result of regular "after-hours" use?