It doesn't even need to be a lifestyle business, nor in flyover country. I live on the Maine coast working for a large company. We even have a big office here! I'm mid 30's, wife, kid, and we have a nice balance. Yeah sometimes I work a bit more than I'd like, but 40 hours per week is normal, and for the times I work more than that, it's more than offset by my 20 minute traffic-doesnt-exist commute. I feel very fortunate to live somewhere that other people visit on vacation, but getting here isn't really that challenging.
Portland (the original!) has a small but growing startup scene if that's your thing. It also has some of the best food and beer in the country, which is a distraction I admit.