Yes, it says that in the README. Plenty of people use other operating systems, though.
I don't see any mention of Mac at all in the Readme, and I find the "etc" part confusing. For example, I use FreeBSD. PS4 is based on FreeBSD. Does FreeBSD go under the "etc" part? If not then what does?
> MTuner supports Windows, PlayStation 4 and PlayStation 3
> out of the box. Additionally, any platform with GCC or
> Clang based cross compiler can easily be supported with a
> little extra work. Instrumentation API comes with full
> source code which means it’s a matter of porting a few
> routines to get it up and running on additional platforms.
http://mtuner.net/doc/overview_compilers.html