Depends on your simulation. Are you using your workstation to do molecular dynamics? Or turbulent fluid simulations? A little extra randomness in two bits every day won't hurt you.
See e.g. this paper by Walker and Betz from the San Diego Supercomputing Centre (paper from XSEDE '13) on the effect of ECC on GPUs for MD simulations: https://dl.acm.org/citation.cfm?id=2484774