There are several ways to do it: compile to C++, compile to the Neko VM, or use Node (there are official bindings: https://github.com/HaxeFoundation/hxnodejs) In development it's Haxe (which is a lovely language to work with) but in production it can be something you're familiar with.
I like Haxe. I coded in AS3 for years.
What I wanted to know was if anyone could share their experience when running a Haxe target on a server.
Haxelib (the Haxe package manager) client and server are both written in Haxe. Also try.haxe.org and kodegarden.org clients+servers are also written in Haxe.