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Fwiw, at least in the places I've lived in the US,

The informal supply chain for such things is usually well established, and easy to find (and triangulate) quality within.

These mushrooms grow readily and in many places naturally in abundance (though as with all mushrooms of course you wouldn't want to pick them without being certain of your own abilities).

Erowid.org is a great resource for self-education btw.

Magic mushrooms are perhaps the most trustworthy black-market good you can acquire. Unlike generic white powders or pills, mushrooms are difficult to counterfeit/substitute/adulterate, and cultivation is extremely easy. The enterprising individual can acquire some spores and grow their own.

You may want to research ayahuasca as a depression treatment.