A python application can be anywhere from 10x to 50x slower than a native application. It also probably consumes at least 5x more memory.
Writing the same app in a compiled language is not even an optimization. It's just baseline work to ensure the code is not super slow.
Like, if you know you will sort a list of 10 items, choosing quicksort from the stdlib instead of bubble sort is not even an optimization. It's just common sense.