Use build-id (https://fedoraproject.org/wiki/Releases/FeatureBuildId), strip the debug info into its own object file, and point gdb at your debug objects when it comes time to debug.
Lean distributable binaries, yet still debugable. Win-win.
Lean distributable binaries, yet still debugable. Win-win.
The next step up in convenience is having the source-level debugger understand how to fetch the corresponding source files from a server based on revision IDs or content hashes.
Between those two features, you can open a core dump on any machine, and immediately have access to both debug info and source without manually mucking around with anything. If you spend a lot of time looking at core dumps from a myriad of different programs and versions of those programs, this is a lifesaver.