Indeed, I was on PPIs for years. Before them, I used to wake up choking on bile, I was eating tums like candy. Then I changed my diet and starting taking baking soda in water of all things. When travelling I'll go back on PPIs for the trip, and notice a distinct feeling of unwellness. But I simply don't want to deal with questions of the form; 'what's this white powder in your luggage?' so I deal with it.