I've always thought ctypes a bit of a hack as you get crashes and so on if you're not constantly careful about updating function definitions. It would be much nicer if the compiler could catch the errors, e.g.

    #include "mylib.h"
    PYTHON_WRAP(myfunc, void, float, float...)

Even with cython (please correct me if I'm wrong), the definition needs to be duplicated in the cython script to use it.