I must admit some degree of fantasy fatigue.

The setting I'd want to see for a complex multi-party high-budget drama, is a fictional world in the age of sail. Conquerors, unlikely allies, traders, and even pirates.

It could have social commentary around first contact, exploitation, different belief systems, different social structures, relations with the crown.

And it'd be really ambitious if the cultures involved were somewhat evenly matched. A bit better technology on one side vs. home field advantage and numbers on the other. Possibly diseases going in both directions.