we are lacking 'mind physics' at the moment, all we have is brute force trial and error
There’s some great work in Artificial Gene Networks that tries to tackle this problem. AGNs are mathematically the same as ANNs.
Here’s a paper I wrote in 2008 with about 170 citations that has a lot of relevant references: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538912/
So, yeah, we need to discover the basic physical principle of the brain.
Keep in mind the context of what I'm saying, which is responding to this:
Hinton's caught up in a mind boggling batch of mumbo-jumbo that proves no one understands how the brain actually works
I would argue that modern AI/ML is far past "mumbo jumbo" and provides useful tools, even without a detailed understanding of the brain.