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And I take it using a separate subdomain wont work either? I.E. if you send mail from hi@marketing.example.com it will still hurt frank@example.com so they need to get a different domain?

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It depends on how spam filters are configured, but yes, subdomains can harm root domain's reputations. However, it's generally seen as OK to use subdomains to mitigate reputations being spread to the main domain. As long as you have your records in order to show what's going on, using a subdomain is usually OK.[1]

[1]: http://www.magillreport.com/Spamhaus-Provides-Answers-Part-F...

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