> And you cannot make up for missing keys with key combos.
If you're saying you can't replicate those keys with key combos: Fn-Up Arrow, Fn-Down Arrow, Fn-Left Arrow and Fn-Right Arrow perform PgUp, PgDn, Home, and End, respectively.
If you're saying key combos are not a suitable replacement for those keys being not present: Well, I make do, personally.