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The CYP1A2 gene affects how quickly you metabolize caffeine. Stopping at 3pm may not be enough.

I’ll check my CYP1A2 SNPs on 23andme in the AM and report back.

I'm not sure if that's sarcasm or not. Maybe I'm just not hip.

Not sarcasm at all. Last time I checked, 23andme reports if you’re a fast or slow caffeine metabolizer. I just don’t recall offhand which I am.

Why would that be informative? It doesn’t tell you your protein expression levels nor effective enzymatic activity.