1. The purpose and character of the use, including whether such use is of a commercial nature or is for nonprofit educational purposes;
Source https://en.wikipedia.org/wiki/Fair_use#U.S._fair_use_factors
To be clear, commercial usage doesn't automatically indicate a violation but it would be considered.
* the purpose and character of your use
* the nature of the copyrighted work
* the amount and substantiality of the portion taken, and
* the effect of the use upon the potential market.
(https://fairuse.stanford.edu/overview/fair-use/four-factors/)
You certainly can include copyrighted content in commercial art, for example if it's a single second of a video, the main subject of discussion (such as in a review), a small portion of a complete work (like a quote), and more. Non-commercial use could still affect the potential market for an original (such as by outselling it or defacing it). So a lot of it depends on how much you're using, how you're transforming it, and how it affects the original.
Slavish reproductions can't be copyrighted in the first place, so it's irrelevant.