Do you know much about nlrp3? I read an interesting paper by some investigators who later formed a company called inflazome, but am not sure how the biology or chemistry has evolved since then
https://www.ncbi.nlm.nih.gov/pubmed/?term=nlrp3
They have a histogram by year, and papers looking it over in the context of inflammation are getting quite common. I'd expect some sort of trial to emerge in the next few years, it seems to be getting to that point.