I love 2001, but Inland Empire was almost too much for me, I'm pleased I went to see it though. From Lynch watching Eraserhead or Mulholland Drive (heavily influenced by Ingmar Bergman's Persona) were much more pleasurable.
After leaving an afternoon screening of 2001 directors cut I felt like I'd been taking acid. I really respect Nolan as one of the best modern filmmakers, creating blockbusters with integrity is a big ask.