The only way to exploit these vulnerabilities is to run code on target machines. If that's not possible then the vulnerability is irrelevant. Using firewalls to keep attackers away from your vulnerable machines is a viable strategy in this case.
I'm not discounting that CPUs should operate correctly into the future but the current sandboxes would seem to rely on whims of a CPU's microcode. And the question for browser makers is whether to trust them.
in other words, the halting problem?
So question is, can the Javascript engine generate suboptimal but safe machine code?
We are doomed