https://community.letsencrypt.org/t/help-test-certbot-apache...
It seems they are predicting TLS-SNI-0x going away for a lengthy period of time.
That said, the ALPN proposal is a start.
Though rather than just having it as a mere marker, it should incorporate features to securely indicate which domain label it is attempting to validate and achieve consensus on part of validator and the endpoint being validated.
I am hopeful such a scheme may be useful for future deployments down the road. I think it is likely before there is infrastructure in place utilizing a new mechanism of that kind that current needs will need to be met with one of the other mechanisms.
The speed and resource with which Let's Encrypt is working on solutions to migrate users to non-TLS-SNI validations might well be a signal.