To be fair regulated markets are vulnerable to manipulation today
* know and contractually oblige their customers (the brokerages who gain access to the exchange) to avoid self-trading
* have some preventative mechanisms, e.g. https://www.theice.com/publicdocs/futures_us/exchange_notice...
Both are tragedies and both have a certain element of scale to them, but the Chicago fire was actually much much worse. It killed far more people, made far more people homeless, and destroyed far more economic value (adjusted for inflation).
Yes the current regulated markets have serious problems and are in need of reform. But the scale and scope of fraud and manipulation on all crypto currency markets is vastly larger and far more pervasive.