That's a multi-decade project. They should get started now and will be competitive for whatever the Amazon of 2040 is.
The first step is a backbone rail line that starts in Chapel Hill, runs up to Duke, then through Durham to RTP, to the Airport, and from there to and through Raleigh. Then add spurs and spokes to cover the region and funnel people to the backbone.
Good luck getting the legislature to authorize, much less fund that.