The "fallback to flexbox" part makes me feel like a dinosaur. It wasn't that long ago when we were falling back to tables and floats...
https://caniuse.com/#search=flexbox https://caniuse.com/#search=grid
It's almost like an uncanny valley effect - its similar enough to lure you into a false sense of security, until you realise that defaults for flex-direction are reverse, or it implements flex/flex-grow/flex-shrink/flex-basis completely differently.
I first used flexbox with RN and was kinda baffled when using it on the Web later
There are typical 1D places (stacks of divs, basically), so typical for flex. But since I can do the same with grid I wonder if I should use flex anywhere now (even for 1D).
Note: browser compatibility does not matter for this site