Loader's number has already been mentioned here, but I don't see any mention of the Busy Beaver function[2]. BB(n) is the maximum number of 1s that can be written of a 2-color, n-state halting Turing machine starting from a blank tape and counted after the machine halts. This is of course uncomputable, and grows very quickly. Rayo's function (Rayo(n) = the smallest natural number greater than all natural numbers that can be uniquely identified by a first order set theory expression of at most n symbols) grows even faster, but that requires a non-recursively enumerable set theory or the use of non-provable functions.
[1] https://www.youtube.com/watch?v=QXliQvd1vW0&list=PL3A50BB9C3... [2] http://googology.wikia.com/wiki/Busy_Beaver