Cash-hungry states eye online retail for tax revenue

This seems like it'd be a great opportunity for a new company (or how well does Quicken already do this?). And of course this would be the perfect time to get started, before these kinds of laws start going into effect in more and more states. As a consumer I feel like I'd much rather just pay sales tax to the retailer at the time of purchase rather than having to keep up with it and file it with my tax return (assuming those are my only two choices). But as a small online retailer that'd be such a pain having to pay taxes to 50 different states potentially.