This is an important area of research. The tools we have to measure what's going on inside the brain (fmri, eeg etc) could certainly use an upgrade. Optogenetics is really interesting, and I know there's a lot going on at Berkeley and Stanford and other places to develop new tools, but at this point trying to read the tea leaves in the blood seems to be about all we've got to easily collecting longitudinal molecular biomarker data related to brain biology