I am curious about final package size on various platforms when using this project. The download bundles for the related "fman" project vary considerably -- Win: 1MB; macOS: 23MB; Ubuntu: 39MB. The last number matches my experience with scripted Qt applications, at which point the size is comparable to a typical ~50-70 MB Electron app, at least for compressed downloads. Visual Studio Code is 44 MB on Windows and 65MB on Mac. Scriptable wrappers usually imply that the core Qt shared objects can't be pruned, and the wrappers themselves also add up, so that Windows number is impressive and intriguing!
I would also wonder about performance scaling. Are there good examples of "large" applications where CPython drives the main loop, as opposed to a scripting layer over a C++ core? CPython has a shallower optimization floor than Javascript+V8, and most larger Python GUI applications I've tried had noticeable lags (thinking of several visualization apps, and several Python-centric IDEs). I was similarly skeptical of Javascript-based desktop applications until recently, but Visual Studio Code has been very impressive.