In the longer term, yes; right now, nothing game-changing on the horizon.

The best example would be the work of Made In Space[0]. They've started manufacturing optical fiber on the ISS, where they can reach much greater medium purity than what one can do on Earth. It can, in principle, make fiber optics installations cheaper (less need for repeaters along the way), but the savings are entirely eaten by launch costs (and lack of economies of scale).

The primary output of asteroid mining and space manufacturing will naturally be utilized in space, because we need to bootstrap a pretty large and self-sustaining economy to be able to profitably ship useful quantities of useful stuff downwell.

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[0] - http://madeinspace.us/mis-fiber/

Low or zero gravity can also be a hindrance; how do you mine an asteroid if every wack of the pickaxe also propels you away from said asteroid? Clearly asteroids won't be mined with pickaxes, this is an illustration that gravity is in fact critical for all known terrestrial manufacturing processes!

When considered in this light, shallow gravity wells like the moon or mars, which are cheaper to access from a delta-v perspective are actually super important.

Also, O'neil type cylinder habitats (which I think Bezos favors) are a suitable alternative.