We can deduce from the math that drug companies would not spend nearly as much money on R&D without being able to earn it back. Without patents, they would need a new business model that involved much less cost upfront. We could choose to live with more risk as far as new drugs are concerned, less testing, etc. That might not be a net negative.

No one would make big expensive movies and GoT type shows without copyright. Copyright has the strongest defense, since the creative work is so obvious, concrete, and unique.

I for one wouldn't give away my work in a society without copyright – I'd likely try to found a society with IP protection and then release my work on my terms, which others would hopefully find agreeable.